Journal of Intelligent Computing Zhu Zeng, Qiao Zhang, Yuansheng Wang 15 2 2024 https://doi.org/10.6025/jic/2024/15/2/33-44 https://www.dline.info/jic/fulltext/v15n2/jicv15n2_1.pdf Safety problems of heavy-cargo transportation have been one of the key problems that hinder industrial development. With implementing the “One Belt, One Road” strategy and the “traffic-based state development” strategy, large infrastructural projects increase quickly, which proposes higher requirements for the safety management of heavy-cargo transportation. It is necessary to comprehensively explore and analyze safety accident risk factors of heavy-cargo transportation. This study analyzed the heavy-cargo transportation process systematically, and basic evaluation units were determined and recognized. Risk sources were recognized from five aspects of “workers, vehicles, cargo, environment and management”. A heavy-cargo transportation safety system model was constructed using the integrated DEMATEL-ISM method. The mutual influencing degrees of risk factors were analyzed, and influencing factors and action mechanisms of heavy-cargo transportation safety accidents were explored. Results showed that inadequate professional knowledge of managers is the intrinsic cause of heavy-cargo transportation safety, while human factors and management factors are important causes. Hence, strengthening the safety consciousness and behaviours of workers and improving the professional level of managers are keys to decreasing the rate of heavy-cargo transportation accidents and increasing the safety level.