Journal of Networking Technology Xuejin Wan, Mengdan Gao, Jianchu Kang, Jianling Zhao 8 1 2017 http://www.dline.info/jnt/fulltext/v8n1/jntv8n1_1.pdf This paper introduced a new method to discover the taxi Origin-Destination areas of interest based on functional region division to resolve the problem that taxis distribution is unreasonable. The problem occurs due to dispatching t axis is not in line with the taxi demand in different functional regions during different time periods. The method proposed in this paper clustered t axi Origin-Destination data points of the functional region with the improved DB-SCAN algorithm and yielded the areas of interest with the statistical method named Chi-square distribution. The accuracy and credibility of the method was evaluated through two indicators called coverage and hit ratio and a comparison analysis on situations of different regions. The experiment proved that the proposed method can effectively discover and predicted the taxi Origin- Destination areas of interest in different functional regions in different time periods.